Status:
COMPLETED
Heated Humidified Continuous Positive Airway Pressure and Nasal Physiology
Lead Sponsor:
University of Athens
Conditions:
Obstructive Sleep Apnea Syndrome
Nasal Obstruction
Eligibility:
All Genders
18-80 years
Brief Summary
Nasal continuous positive airway pressure can cause nasal side effects which can compromise compliance to therapy. Humidifiers can attenuate this effect. However, the mechanism by which humidified CPA...
Detailed Description
Introduction-Rationale: Nasal continuous positive airway pressure (CPAP) is considered to be the "gold standard" of obstructive sleep apnoea (OSA) treatment \[1\]. The most common side effects are na...
Eligibility Criteria
Inclusion
- Obstructive sleep apnea syndrome defined as apnea/hypopnoea index greater than 20,
- Initiation of continuous positive airway pressure, and
- Symptomatic nasal obstruction.
Exclusion
- No medication known to influence nasal resistance (antihistamines, vasoconstrictors, vasodilators, topical or systemic steroids, and recreation drugs),
- No smoking,
- No upper or lower respiratory tract disease (e.g. upper respiratory tract infection, rhinitis, sinusitis, chronic obstructive pulmonary disease), including a history of nasal allergy.
Key Trial Info
Start Date :
September 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2009
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00850876
Start Date
September 1 2008
End Date
June 1 2009
Last Update
April 9 2010
Active Locations (1)
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1
Department of Critical Care and Pulmonary Services, Evangelismos Hospital
Athens, Greece, 10675