Status:
COMPLETED
Toxicogenomic and Immunocytotoxic Effects of Propofol and Isoflurane Anesthetics in Patients Undergoing Elective Surgery
Lead Sponsor:
UPECLIN HC FM Botucatu Unesp
Collaborating Sponsors:
Fundação de Amparo à Pesquisa do Estado de São Paulo
Conditions:
Patients in Good Health
Types of General Anesthesia
Eligibility:
All Genders
18-50 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to evaluate if the anesthetics propofol and isoflurane can damage DNA, induce apoptosis, change expression of genes related to apoptosis and DNA repair and change cytokine...
Detailed Description
It is expected that the results provide relevant information to understand the possible adverse effects of anesthetics and contribute to the establishment of strategies aimed at reducing the risks to ...
Eligibility Criteria
Inclusion
- patients in good health American Society of Anesthesia status physical I
- elective minor surgery
- general anesthesia
Exclusion
- smokers
- alcoholics
- previous medication or radiation
Key Trial Info
Start Date :
March 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2009
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT00854178
Start Date
March 1 2008
End Date
December 1 2009
Last Update
January 6 2010
Active Locations (1)
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1
Botucatu Medical School, UNESP
Botucatu, São Paulo, Brazil, 18618-000