Status:
COMPLETED
Phase I Safety Study of DMXAA in Refractory Tumors
Lead Sponsor:
Antisoma Research
Conditions:
Refractory Tumors
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
This was a phase I study aimed at identifying safe doses of DMXAA (now known as ASA404) to be used in future combination studies with chemotherapy.
Detailed Description
This was a multi-centre randomized, double blind study to further characterize the effect of DMXAA on QTc interval, ophthalmic safety and pharmacodynamic effects on tumour blood flow. Patients with r...
Eligibility Criteria
Inclusion
- Evidence of cancer, by histopathology or cytology, which was not amenable to any standard therapy or was refractory to conventional therapy
- Age ≥ 18 years
- Life expectancy of at least 12 weeks
- WHO performance status of 0-2
- Hematological and biochemical indices at the start of treatment:
- Hemoglobin at least 9 g/dl
- Leukocyte count at least 3.0 x 109/l
- Neutrophils at least 1.5 x 109/l
- Platelets at least 100 x 109/l
- Serum Creatinine not higher than140 μmol/l
- Liver function tests (ALT, AST, ALK PHOS) no higher than thrice the upper limit of the reference range, if no demonstrable liver metastases or no more than 5 x upper limit of the normal range in the presence of liver or bone metastases
- Absolute QTc interval values of less than 470 ms in females and less than 450 ms in males as assessed by the Investigator
- Presence of a lesion which was amenable to dynamic MRI
- Written informed consent and the ability of the patient to co-operate with treatment and follow up
Exclusion
- Radiotherapy (except for palliative reasons), endocrine therapy, immunotherapy or chemotherapy during the previous four weeks prior to treatment
- Pregnant or lactating women were excluded
- Patients who were poor medical risks because of non-malignant systemic disease, as well as those with active uncontrolled infection
- Current malignancies at other sites
- Significant history of recreational drug abuse
- Glucocorticosteroids in doses exceeding those required for physiological replacement within the previous 2 weeks
- Skin lesions that may prevent long-term ECG acquisition
- Body mass index above 30 kg/m2
- Patients who were taking certain medications
- Patients with clinical evidence of brain metastases
- Patients with certain cardiac conditions
- Advancing or unstable ischemic heart disease
- Pacing devices and/or implantable cardiovertor-defibrillator
- Significant cardiovascular disease or any unstable cardiovascular disease
- Non-sustained or sustained atrial and/or ventricular tachyarrhythmias
- Atrial fibrillation (including paroxysmal atrial fibrillation) or atrial flutter
- Bundle Branch Block, any stable intra-cardiac conduction abnormality with QRS complex \> 120 ms, any unstable intra-cardiac conduction abnormality
- Sick sinus syndrome, or sinus pauses \> 2 seconds
- Known atrial and/or ventricular ectopic beats \> 10/hour
- Fixed second degree AV block, transient or fixed third degree AV block
- History of documented ventricular flutter, ventricular fibrillation, Torsade de Pointes tachycardia
- Patients who had previously received anthracyclines or other known cardiotoxic medication
- Women with breast implants as these may have interfered with the recording of the ECG
- Patients with severe electrolyte abnormalities and patients in whom transient electrolyte abnormalities may have been expected during any visit of the study
- Patients in whom concomitant neurotropic drug therapy was known to change or was likely to change during the course of the study, where such therapy was likely to affect the patients ERG measurement
- Ophthalmic conditions where in the opinion of the investigator they might affect the recording of the ERG
Key Trial Info
Start Date :
May 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2004
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT00856336
Start Date
May 1 2003
End Date
January 1 2004
Last Update
March 5 2009
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.