Status:
COMPLETED
Expiratory Muscle Training for Persons With Neurodegenerative Disease
Lead Sponsor:
VA Office of Research and Development
Collaborating Sponsors:
University of Florida
Conditions:
Parkinson's Disease
Multiple Sclerosis
Eligibility:
All Genders
35-80 years
Phase:
PHASE2
PHASE3
Brief Summary
Respiratory difficulty is one of the primary factors leading to death in patients with Parkinson's Disease (PD) and Multiple Sclerosis. Both diseases are progressive degenerating diseases that cause d...
Detailed Description
The proposed investigation will: Determine if 5 weeks of Expiratory Muscle Strength Training (EMST) increases maximal expiratory driving pressure (MEP) and improves swallow, cough and breathing funct...
Eligibility Criteria
Inclusion
- Multiple Sclerosis Participants
- Diagnosis of primary, secondary, or relapsing-remitting MS by a neurologist
- Over 85% of the patient populations that come from the study sites demonstrate relapsing-remitting MS with an average relapse frequency of once every 3 years
- Parkinson's Disease Participants
- Hoehn \& Yahr, stage II and III as indicated by certified movement disorders neurologist
- All Participants
- Between 35 and 80 years of age
- Non-smoking or no smoking within the previous five years
- No history of head and neck cancer, asthma or COPD, untreated hypertension
- Sufficient facial muscle strength so as to achieve and maintain adequate lip closure around a circular mouthpiece
- Cognition within normal limits as determined by the: Mini Mental Status Exam (MMSE; 1975No neurological (other than MS or PD) condition which adversely affects respiratory muscle or gas exchange system
- Reduced MEP's compared to published normative data for age and sex
- Reduced expiratory peak flow rates (6-8 L/s for young to middle age adults and 3.6 L/s for 65 and older) during voluntary cough production for age and sex (Bolser, personal communication; Smith-Hammond \& Goldstein, 2006)
- Participant report of symptoms related to swallow impairment
Exclusion
- DBS
- COPD
- Asthma
- Smoking or smoking within preceding 5 years
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2014
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT00856518
Start Date
March 1 2009
End Date
August 1 2014
Last Update
February 10 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
North Florida/South Georgia Veterans Health System, Gainesville, FL
Gainesville, Florida, United States, 32608