Status:
COMPLETED
Glucagon-like Peptide 1 (GLP-1) and Endothelial Dysfunction in Metabolic Syndrome
Lead Sponsor:
University of Rome Tor Vergata
Collaborating Sponsors:
Merck Sharp & Dohme LLC
Conditions:
Metabolic Syndrome
Eligibility:
All Genders
20-60 years
Phase:
NA
Brief Summary
Glucagon-like peptide 1 (GLP-1) is an intestinal peptide hormone secreted in a nutrient-dependent manner that stimulates the pancreatic beta cells to secrete more insulin in response to the same amoun...
Detailed Description
Subjects meeting the entrance criteria will be studied in a quiet room with a temperature of approximately 22°C. While the participants are supine, a 20-gauge Teflon catheter will be inserted into the...
Eligibility Criteria
Inclusion
- Otherwise healthy individuals aged between 20 and 60 years
- Must satisfy 3 out of the 5 listed criteria for the diagnosis of the metabolic syndrome (ATP III) will be included
Exclusion
- Pregnancy
- Liver disease
- Pulmonary disease
- Renal insufficiency
- Coronary heart disease
- Heart failure
- Peripheral vascular disease
- Coagulopathy
- Any disease predisposing to vasculitis or Raynaud's phenomenon
- Bleeding disorders
- Kidney stones
- Platelet count \< 150,000/ml blood
- Prothrombin time/partial thromboplastin time (PT/PTT) \> 1 second above the normal range, and positive tests for HIV, or hepatitis B or C
- Subjects who are taking any kind of medication will not be included in this study; therefore, antihypertensive and/or lipid-lowering drugs will be discontinued at least 2 weeks before enrollment into this study
- All subjects will be told to refrain from alcohol, beverages containing caffeine, or smoking for at least 24 hours before the study is performed
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2012
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00856700
Start Date
November 1 2008
End Date
June 1 2012
Last Update
December 11 2013
Active Locations (1)
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1
Tor Vergata University
Rome, Italy, 90100