Status:
COMPLETED
Clinical Studies on Bile Acids in Barrett's Esophagus
Lead Sponsor:
US Department of Veterans Affairs
Conditions:
Gastroesophageal Reflux Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study has two major goals: 1. To determine the effects of bile salts on causing DNA injury and activating signaling pathways that promote growth in cells from the esophagus of patients who have ...
Detailed Description
Patients who have been scheduled for elective endoscopic examination at the Dallas VA Medical Center for the evaluation of GERD or Barrett's esophagus will be invited to participate in the study. Pati...
Eligibility Criteria
Inclusion
- Patients who have been scheduled for elective endoscopic examination at the Dallas VA Medical Center for the evaluation of GERD or Barrett's esophagus
Exclusion
- Patients unwilling or unable to provide informed consent
- Patients with esophageal carcinomas
- Patients with esophageal varices
- Patients taking warfarin or clopidogrel
- Coagulopathy that precludes safe biopsy of the esophagus
- Comorbidity that precludes safe participation in the study
- Allergy to omeprazole or UDCA
- Pregnancy
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2015
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00858858
Start Date
March 1 2009
End Date
February 1 2015
Last Update
April 30 2015
Active Locations (1)
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1
VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX
Dallas, Texas, United States, 75216