Status:
COMPLETED
Glutathione Metabolism in Adolescents With Type 1 Diabetes - Study A
Lead Sponsor:
Nemours Children's Clinic
Collaborating Sponsors:
Juvenile Diabetes Research Foundation
Conditions:
Diabetes Mellitus, Type 1
Eligibility:
All Genders
14-18 years
Phase:
NA
Brief Summary
Glutathione is normally present at high (millimolar) levels in blood and plays an important role in the body's defense against oxidative stress, that is, against the damage caused to the body by react...
Detailed Description
Adolescents with uncomplicated T1D will receive two, 5-hour infusions of deuterium-labeled cysteine on 2 separate days, a few weeks apart, while blood glucose will be maintained, using intravenous ins...
Eligibility Criteria
Inclusion
- Type 1 diabetes, using usual criteria such as: glycosuria, hyperglycemia prior to treatment
- BMI \<25 kg/m2
- Age 14-18
- HbA1c\>7.5%
- No evidence of diabetic complications
- Written informed consent from parents or legal guardian, and assent from patient
Exclusion
- Presence of significant anemia (hemoglobin \<11g/dL)
- Presence of intercurrent illness such as infection
- Presence of chronic disease such as other endocrine deficiency, chronic respiratory or cardiac disease
- Chronic use of medication other than insulin
- Use of vitamin or mineral supplements within 2 weeks of study
Key Trial Info
Start Date :
June 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2009
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00858897
Start Date
June 1 2007
End Date
February 1 2009
Last Update
July 10 2023
Active Locations (1)
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1
Nemours Children's Clinic
Jacksonville, Florida, United States, 32207