Status:
COMPLETED
Mechanisms of Endothelial Cell Dysfunction in Sleep Apnea
Lead Sponsor:
Weill Medical College of Cornell University
Collaborating Sponsors:
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Obstructive Sleep Apnea
Hypoxemia
Eligibility:
All Genders
21+ years
Phase:
NA
Brief Summary
Sleep apnea is a common sleep disorder characterized by temporary stops in breathing during sleep and has been associated with the development of cardiovascular disease. This research will investigate...
Detailed Description
The importance of this project is to investigate mechanisms of vascular disease in sleep apnea and determine pathways for intervention, aiming to prevent the development of cardiovascular disease in t...
Eligibility Criteria
Inclusion
- Study Group 1: Sleep Apnea
- 21 years or older
- Presence of intermittent hypoxemia (IH) and obstructive sleep apnea (OSA)
- No diagnosis of hypertension, coronary artery disease, diabetes, stroke, or evidence of underlying vascular disease
Exclusion
- Smoking
- Pregnancy
- Known cardiovascular disease, stroke, or diabetes
- Current or previous treatment for sleep apnea
- Central or Cheyne-Stokes sleep apnea
- Use of supplemental oxygen at night
- Alcohol abuse
- Regular use of sedatives
- Regular use of aspirin or cholesterol lowering agents
- Study Group 2: Normal Controls
- Inclusion Criteria:
- 21 years or older
- No diagnosis of intermittent hypoxemia (IH) or obstructive sleep apnea (OSA)
- No diagnosis of hypertension, coronary artery disease, diabetes, stroke, or evidence of underlying vascular disease
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2015
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT00859950
Start Date
April 1 2009
End Date
August 1 2015
Last Update
February 4 2019
Active Locations (1)
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1
Weill Cornell Medical College - Weill Cornell Pulmonary Associates
New York, New York, United States, 10021