Status:
COMPLETED
A Comparison of Measurements of Ketone Body Flux Versus Ketone Body Concentration as a Pharmacodynamic Marker of Hepatic Fatty Acid Oxidation (0000-110)
Lead Sponsor:
Merck Sharp & Dohme LLC
Conditions:
Diabetes
Eligibility:
MALE
18-55 years
Phase:
PHASE1
Brief Summary
This study will compare two approaches to the measurement of fatty acid oxidation (ketone body flux and ketone body concentration) and determine which method demonstrates superior sensitivity and vari...
Eligibility Criteria
Inclusion
- Subject has a Body Mass Index of 18-25 kg/m2 OR 29-40 kg/m2
- Subject has been a nonsmoker or has not used nicotine for the past 6 months
Exclusion
- Subject has a history of diabetes mellitus
- Subject has a history of stroke, chronic seizures, or other neurological disorder
- Subject has a history of cancer, except certain skin cancers
- Subject consumes more than 3 alcoholic beverages per day
- Subject consumes more than 6 servings of caffeinated beverages per day
- Subject has multiple and/or severe allergies to food or drugs
- Subject has allergy or sensitivity to eggs or soy
- Subject regularly uses illicit drugs or has a history of drug or alcohol abuse
Key Trial Info
Start Date :
March 2 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 8 2009
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00860392
Start Date
March 2 2009
End Date
July 8 2009
Last Update
November 27 2017
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