Status:
COMPLETED
A Methodology Study in Healthy Subjects to Evaluate the Effect of AZD8309 After Nasal Administration of Lipopolysaccharide (LPS)
Lead Sponsor:
AstraZeneca
Conditions:
Healthy
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
The purpose of this methodology study is to evaluate the effect of AZD8309 on cells and inflammatory biomarkers in nasal lavage and blood after nasal challenge with lipopolysaccharide (LPS)
Eligibility Criteria
Inclusion
- Healthy men or healthy, permanently sterilized, women aged 18 to 50 years inclusive, non-smokers or ex-smokers, Body Mass Index 18 to 30 kg/m2 and minimum body weight of 50 kg
- Blood neutrophil count above 2.2x10\^9/L
Exclusion
- Clinical relevant disease and/or abnormality
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2009
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00860821
Start Date
March 1 2009
End Date
October 1 2009
Last Update
October 28 2009
Active Locations (1)
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1
Research Site
Malmo, Sweden