Status:
COMPLETED
Real Time Myocardial Contrast Echocardiography and Dobutamine Stress Perfusion Magnetic Resonance Imaging
Lead Sponsor:
University of Nebraska
Conditions:
Kawasaki Disease
Heart Disease
Eligibility:
All Genders
12-50 years
Brief Summary
The present study is designed to: 1. investigate the safety and efficacy of Real time myocardial echocardiography (RT-MCE) in adolescents and adults ages 12-50 with congenital and acquired congenital...
Detailed Description
Individuals will be identified from the cardiology database and consented during their routine follow up visits. Exercise stress, transthoracic echocardiography and cardiac MR are part of standard med...
Eligibility Criteria
Inclusion
- • Age between 12 years and 50 years.
- Male or female.
- History of repaired congenital heart disease including atrial septal defects, aortic valve disease, tetralogy of fallot, transposition of great arteries and anomalous left coronary artery from pulmonary artery.
- History of sequelae of heart disease acquired as an infant or child, including Kawasaki disease and coronary ectasia, and patients post anthracycline chemotherapy.
- Ability to perform Supine bicycle stress with contrast echocardiography as determined by primary cardiologist and/or Dr. Shelby Kutty.
- Ability to perform CMR with dobutamine stress as determined by the patients primary cardiologist and/or Dr. Shelby Kutty
- Signed informed consent and assent as applicable.
Exclusion
- • Atrial or ventricular arrythmias that cannot be controlled to heart rates \< 70/min
- Intracardiac shunts
- Known hypersensitivity to perflutren
- Known hypersensitivity to Dobutamine
- Congestive heart failure in NYHA class II, III or IV
- Claustrophobia or any other reason patient is unable to perform CMR (i.e. ferromagnetic implants causing significant artifact that alters image quality, presence of pacemaker, AICD, etc.)
- Pregnant or possibly pregnant (based on history/information obtained from the patient) or breast feeding
Key Trial Info
Start Date :
April 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2019
Estimated Enrollment :
124 Patients enrolled
Trial Details
Trial ID
NCT00861848
Start Date
April 1 2009
End Date
March 1 2019
Last Update
September 25 2023
Active Locations (1)
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1
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198