Status:
COMPLETED
Hydrocortisone Use After Etomidate in Intensive Care
Lead Sponsor:
University Hospital, Grenoble
Conditions:
Patient Admitted in Reanimation
Eligibility:
All Genders
18-79 years
Phase:
PHASE3
Brief Summary
the objective of the study is to assess the value of substitution with 200mg/24h of hydrocortisone for 48 hours for patients in intensive care who have received a single injection of etomidate
Detailed Description
Etomidate is a hypnotic widely used for patients in intensive care who require rapid induction, because of its short duration of action, its excellent cardiovascular tolerance and maintenance of cereb...
Eligibility Criteria
Inclusion
- Patients who received an unique injection of etomidate in pre-hospital situation or at "déchocage" in the previous 6 hours.
- informed consent signed by the patient or the reliable person
- affiliation to a regime of social security
Exclusion
- persons aimed at the articles L. 1121-5 à L. 1121-8 of the french code of public health
- toxic shock requiring a treatment by HSHC inn accordance with the criteria of Annane et Al. \[13\]
- purpura fulminans
- chronicle suprarenal insufficiency
- patients likely to present an acute suprarenal insufficiency : current treatment with antifungal : ketoconazole or fluconazole, known HIV infection, Sheehan syndrome
- corticotherapy in the 6 last months
- initiation of hydrocortisone therapy out of the study
- survival estimated at less than 48 hours
- no benefits of social security
- refusal to participate by patient or reliable person
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2010
Estimated Enrollment :
106 Patients enrolled
Trial Details
Trial ID
NCT00862381
Start Date
October 1 2008
End Date
July 1 2010
Last Update
July 26 2010
Active Locations (2)
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1
Réanimation polyvalente déchocage, centre hospitalier de la région Annecienne
Annecy, France
2
Pôle d'anesthésie - réanimation, University Hospital of Grenoble
Grenoble, France