Status:
TERMINATED
Evaluation of Vancomycin Treatment of Infections Due to Staphylococcus Aureus
Lead Sponsor:
University of Nebraska
Conditions:
Staphylococcus Aureus
Eligibility:
All Genders
19+ years
Brief Summary
Objective: The objective of the study is to evaluate the ability of current vancomycin dosing strategies to attain the pharmacodynamic target of an area under the curve (AUC) to minimum inhibitory con...
Detailed Description
Study Design: This is a prospective cohort study with a retrospective chart review component. Inclusion and Exclusion Criteria: Inpatients of The Nebraska Medical Center will be included if they are ...
Eligibility Criteria
Inclusion
- 19 years of age or older
- Admitted to an inpatient care unit at The Nebraska Medical Center
- Prescribed intravenous vancomycin therapy with a dosing interval of 24 hours or less
- Vancomycin therapy that lasts for at least 3 doses or 5 half-lives as scheduled with no dosage changes
Exclusion
- Estimated creatinine clearance (CrCl) less than 30 ml/min using the Cockroft-Gault equation (in patients over the age of 65 a SCr of 1.0 mg/dL will be assumed for all patients with a reported SCr less than 1.0 mg/dL). Ideal body weight will be used for the Cockroft-Gault equation unless the actual body weight is less than the ideal body weight.
- Patients requiring any form of dialysis
- Pregnancy
Key Trial Info
Start Date :
April 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 3 2011
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT00862862
Start Date
April 1 2009
End Date
February 3 2011
Last Update
August 23 2023
Active Locations (1)
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1
Unversity of Nebraska Medical Center
Omaha, Nebraska, United States, 68198