Status:
COMPLETED
Cutaneous DNA Damage Caused by UV-A Irradiation
Lead Sponsor:
University Hospital, Grenoble
Collaborating Sponsors:
Commissariat A L'energie Atomique
Conditions:
Healthy Volunteers
Eligibility:
MALE
18-35 years
Phase:
NA
Brief Summary
The DIMUVA study aims to evaluate the correlation between cutaneous phototype and the nature and quantity of damage caused to cutaneous DNA after exposure to UV-A radiation.
Detailed Description
Due to their capacity to damage Deoxyribonucleic acid (DNA), Ultra-Violet (UV) radiation is one of the causes of skin cancers. Until recently, the genotoxic effects of UV-A radiation, were poorly ide...
Eligibility Criteria
Inclusion
- Male,
- Between 18 and 35 years old,
- Healthy volunteers,
- Cutaneous phototype 2 or 4 according to the Fitzpatrick classification,
- Affiliation to the French Social Security.
Exclusion
- History of photosensibility,
- Active smoking or stopped since less than one year,
- Dermatological pathology or treatment contra-indicating cutaneous irradiation and skin biopsies,
- Any chronic pathology susceptible to interfere with the evaluations related to the protocol,
- Allergy to local anaesthetics,
- Volunteers who take drugs and/or food complements acting on oxidative stress in the 8 weeks preceding inclusion,
- Volunteers who have take paracetamol or aspirin within 7 days prior to the inclusion visit,
- Subject in exclusion period for another biomedical research study,
- Subject having exceeded the threshold of annual compensation for biomedical research.
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2009
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00864955
Start Date
March 1 2009
End Date
July 1 2009
Last Update
September 3 2009
Active Locations (2)
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1
Centre d'investigation Clinique ,University Hospital Grenoble
Grenoble, France, 38043
2
Department of Dermatology, University Hospital Grenoble
Grenoble, France, 38043