Status:
TERMINATED
Pharmacotoxicology of Trichloroethylene Metabolites
Lead Sponsor:
University of Florida
Conditions:
Healthy
Eligibility:
All Genders
22-60 years
Phase:
NA
Brief Summary
This project focuses on the kinetics, metabolism and human toxicology of dichloroacetate (DCA)and tyrosine catabolism. The hypothesis is that tyrosine metabolism will be greatest in subject who harbor...
Detailed Description
Specific Aim 4. Quantify the effects of DCA on human tyrosine metabolism and on its own biotransformation in relation to dose and genotype.
Eligibility Criteria
Inclusion
- Adults scheduled for elective surgery for benign liver disease.
- Normal EKG and history
- Normal baseline labs
Exclusion
- Pregnancy
- severe anemia, defined as a hematocrit \< 30%.
- diabetes mellitus
- renal insufficiency, defined as a serum creatinine \> 1.5 mg/dl or a creatinine clearance \< 60 ml/min
- elevated liver enzymes
- psychiatric illness requiring medication
- primary biliary cirrhosis or any other form of cirrhosis
- viral hepatitis or non-viral steatohepatitis
- coronary heart disease, defined as requiring daily administration of anti-anginal drugs or as New York Heart Association Class III or IV heart failure
- malignancy of any type in any anatomical location
Key Trial Info
Start Date :
August 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2012
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT00865514
Start Date
August 1 2011
End Date
January 1 2012
Last Update
June 3 2015
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Florida
Gainesville, Florida, United States, 32610