Status:
COMPLETED
Pharmacokinetic Study Of Ibuprofen Injection (IVIb) In Healthy Adult Subjects
Lead Sponsor:
Cumberland Pharmaceuticals
Conditions:
Healthy
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
The primary objective of this study is to evaluate the pharmacokinetic profile of a single dose of IVIb administered over 5-7 minutes.
Eligibility Criteria
Inclusion
- Healthy volunteers between the ages of 18 and 65 years (at the time of consent).
Exclusion
- Participants lacking good venous access in both arms.
- History of allergy or hypersensitivity to NSAIDs or any component of intravenous ibuprofen.
- Have never taken aspirin or ibuprofen
- History of abuse of alcohol or other drugs in the 2 months before CTM administration.
- Have used prescription drugs (not including oral contraceptives) within 14 days before CTM administration or have used aspirin within one week before CTM administration or over-the-counter pain relievers (NSAIDs or acetaminophen) within 3 days before CTM administration.
- Have taken investigational drugs within 30 days before CTM administration.
- Have donated blood or blood products within 30 days before CTM administration.
- Be pregnant or nursing.
- Have had breast cancer.
- Have a clinically significant laboratory test
- Presence or history of the following conditions: asthma, bleeding tendency, hypertension, heart failure, peptic ulcer disease, inflammatory bowel disease, or any other gastrointestinal disorder, renal or hepatic disease..
- Have a calculated creatinine clearance (estimated by means of the Cockcroft-Gault equation) of \< 75mL/min
- Inability to understand the requirements of the study. Participants must be willing to provide written informed consent (as evidenced by signature on an informed consent document approved by an Institutional Review Board \[IRB\]), and agree to abide by the study restrictions.
- Refusal to provide written authorization for use and disclosure of protected health information
- Be otherwise unsuitable for the study, in the opinion of the Investigator.
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2009
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00867880
Start Date
March 1 2009
End Date
June 1 2009
Last Update
December 15 2014
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Centre for Pharmaceutical Research
Underdale, South Australia, Australia, 5032