Status:
COMPLETED
Pneumocystis in Pathogenesis of HIV-associated Emphysema
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
HIV Infections
Pneumocystis Pneumonia
Eligibility:
All Genders
18+ years
Brief Summary
A. Statement of Hypotheses: HIV-infected patients have an increased incidence of emphysema compared to non-HIV-infected smokers, and it has been hypothesized that this accelerated disease progression...
Detailed Description
We propose that Pneumocystis accelerates emphysema in HIV-infected smokers by stimulating inflammation and tissue destruction. This grant will examine the role of co-infection with Pneumocystis in the...
Eligibility Criteria
Inclusion
- Subject is Male / Female 18years of age or older.
- Subject has been previously determined to be HIV-infected or has been participating in the Pitt Men's study or is seen at the UPMC HIV/AIDS program
Exclusion
- Subject is experiencing acute onset of shortness of breath, cough, fevers or heart conditions problems such as tachycardia, angina or arrhythmias
- Female subject has told us she is pregnant (this might affect pulmonary function values,we will not require pregnancy testing.)
- Subject has had an MI, CVA, or cardiovascular event within the past 3 months.
- Subject has had eye or abdominal surgery within past 3 months.
Key Trial Info
Start Date :
August 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2013
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT00869544
Start Date
August 1 2007
End Date
July 1 2013
Last Update
October 8 2020
Active Locations (1)
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1
UPMC Montefiore Hospital, CTRC MUH, Keystone Bldg.
Pittsburgh, Pennsylvania, United States, 15213