Status:
RECRUITING
Dominantly Inherited Alzheimer Network (DIAN)
Lead Sponsor:
Washington University School of Medicine
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Alzheimer's Disease
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.
Detailed Description
Dominantly inherited Alzheimer's disease (AD) represents less than 1% of all cases of AD and is an important model for study because the responsible mutations have known biochemical consequences that ...
Eligibility Criteria
Inclusion
- Written informed consent obtained from participant and collateral source prior to any study-related procedures.
- Aged 18 (inclusive) or older and the child of an affected individual (clinically or by testing) in a pedigree with a known mutation for ADAD.
- Cognitively normal to very mild or mild cognitive impairment (CDR score range 0-1.0). Primary enrollment will focus on the recruitment of asymptomatic adult children who are more than 15 years younger than the estimated age of symptom onset. Enrollment of new participants with moderate cognitive impairment is allowed with the prior approval of the DIAN Coordinating Center.
- Has two persons who are not their full-blooded siblings who can serve as collateral sources for the study.
- Fluent in a language approved by the DIAN Coordinating Center at about the 6th grade level (international equivalent) or above.
Exclusion
- Under age 18
- Medical or psychiatric illness that would interfere in completing initial and follow-up visits
- Requires nursing home level care
- Has no one who can serve as a study informant
Key Trial Info
Start Date :
January 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2026
Estimated Enrollment :
700 Patients enrolled
Trial Details
Trial ID
NCT00869817
Start Date
January 1 2009
End Date
July 1 2026
Last Update
October 28 2025
Active Locations (26)
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1
Mayo Clinic Jacksonville
Jacksonville, Florida, United States, 32224
2
Indiana University-Indiana Alzheimer Disease Center
Indianapolis, Indiana, United States, 46202
3
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
4
Washington University in St. Louis School of Medicine
St Louis, Missouri, United States, 63108