Status:
COMPLETED
Investigation of Lithium on Signal Transduction, Gene Expression and Brain Myo-Inositol Levels in Manic Patients
Lead Sponsor:
Wayne State University
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Bipolar Disorder
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
This study investigates the effects of Lithium treatment on signal transduction pathways, gene expression and brain neurochemistry and structure in patients with Bipolar disorder. It is hypothesized t...
Detailed Description
This study investigates the effects of blinded lithium treatment longitudinally in patients with bipolar disorder. At baseline and at multiple time points following the initiation of lithium treatment...
Eligibility Criteria
Inclusion
- Meet diagnostic criteria for Bipolar Mood Disorder determined by DSM-IV (SCID)
Exclusion
- Meeting criteria for any other DSM-IV axis I disorder
- Psychoactive substance abuse or dependence within the past 1 year
- Medical conditions placing patients at increased risk for lithium treatment (including renal disease, hepatic disease, hematological disease)
- Devices/implants or conditions which preclude MRI investigation (including cardiac pacemaker/ICD, aneurysm clips, neurostimulator device, metallic fragments in or near the eye,claustrophobia)
Key Trial Info
Start Date :
March 1 1996
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2004
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT00870311
Start Date
March 1 1996
End Date
April 1 2004
Last Update
March 27 2009
Active Locations (1)
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1
Wayne State University School of Medicine
Detroit, Michigan, United States, 48201