Status:
COMPLETED
Prevalence and Pathogenesis of Lung Disease in a Large HIV Cohort-coordinating Center
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
University of California, San Francisco
University of Washington
Conditions:
HIV Infections
Emphysema
Eligibility:
All Genders
18+ years
Brief Summary
Despite the availability of highly active antiretroviral therapy (HAART), lung diseases remain a leading cause of morbidity and mortality in those with HIV infection. There have been no large-scale st...
Detailed Description
HIV-infected patients have an increased incidence of emphysema compared to non-HIV-infected patients, and it has been hypothesized that this accelerated disease progression is the result of one or mor...
Eligibility Criteria
Inclusion
- Subject is Male / Female 18years of age or older.
- Subject has been previously determined to be HIV-infected or is participating in the The Multicenter AIDS Cohort Study (MACS) or the Women's Interagency Health Study (WIHS)
Exclusion
- Subject is experiencing acute onset of shortness of breath, cough, fevers or heart conditions problems such as tachycardia, angina or arrhythmias.
- Female subject has told us she is pregnant (this might affect pulmonary function values,we will not require pregnancy testing.)
- Subject has had an MI, CVA, or cardiovascular event within the past 3 months.
- Subject has had eye or abdominal surgery within past 3 months.
- Active TB by documentation or self reported will be exclusion criteria to the study.
- Subjects will be excluded from the study if they are unable to sign consent, weigh \> 300 pounds due to technical difficulties with the CT/EBCT scanner, or have been exposed to approximately 10 rads in the previous 12 months (i.e., 2 diagnostic CT scans or 4 cardiac caths or other fluoroscopic exams).
Key Trial Info
Start Date :
January 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2016
Estimated Enrollment :
407 Patients enrolled
Trial Details
Trial ID
NCT00870857
Start Date
January 1 2009
End Date
August 1 2016
Last Update
August 26 2025
Active Locations (2)
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1
UCLA
Los Angeles, California, United States, 90095
2
UCSF
San Francisco, California, United States, 94118