Status:
COMPLETED
Airway Macrophages and Sputum Milieu in Adult Subjects With Airflow Obstruction
Lead Sponsor:
University of Nebraska
Collaborating Sponsors:
VA Nebraska Western Iowa Health Care System
Conditions:
Pulmonary Disease, Chronic Obstructive
Bronchitis, Chronic
Eligibility:
All Genders
50-75 years
Brief Summary
Airway macrophage impairment is a central feature in the immunopathogenesis of chronic obstructive pulmonary disease, regardless of smoking status.
Detailed Description
In the United States, a variety of farming operations can generate significant amounts of dust. Chronic organic dust exposure to workers in this industry can result in several respiratory health condi...
Eligibility Criteria
Inclusion
- Medically stable to participate in induced sputums
- Group One: Smoked less than 100 cigarettes in their lifetime Quit smoking greater than 10 years ago Pre-bronchodilator FEV1/FVC \> 70% Pre-bronchodilator FEV1 % predicted \> 80%
- Group Two: Greater than a 20-pack year tobacco history Smoked in the last two years Post-bronchodilator FEV1/FVC \< 70%
- Group Three:Have less than a 20-pack year tobacco history Quit smoking greater than 20 years ago Post-bronchodilator FEV1/FVC \< 70%
Exclusion
- Personal history of lung cancer
- Pregnancy
- Personal history of autoimmune disease
- Currently taking oral/parental corticosteroids
- Personal history of upper or lower respiratory tract infection in the prior four weeks
Key Trial Info
Start Date :
August 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2009
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00871637
Start Date
August 1 2008
End Date
June 1 2009
Last Update
September 7 2023
Active Locations (1)
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1
University of Nebraska
Omaha, Nebraska, United States, 68198