Status:
COMPLETED
Identifying Brain and Genetic Markers of Sertraline Treatment Response in People With Social Anxiety Disorder
Lead Sponsor:
University of Michigan
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Anxiety Disorders
Eligibility:
All Genders
18-55 years
Brief Summary
This study will attempt to identify gene and brain activity markers that predict whether people with social anxiety disorder will respond to selective serotonin reuptake inhibitor medications.
Detailed Description
Social anxiety disorder (SAD) is an anxiety disorder characterized by excessive fear and avoidance of social situations. Selective serotonin reuptake inhibitors (SSRIs) are a medication commonly presc...
Eligibility Criteria
Inclusion
- For social anxiety disorder group:
- Current diagnosis of social anxiety disorder, generalized subtype
- Physically healthy, as confirmed by comprehensive medical history, physical exam, and laboratory testing
- For healthy control group:
- Never been diagnosed with either Axis I or Axis II mental disorders
- Physically healthy, as confirmed by comprehensive medical history, physical exam, and laboratory testing
Exclusion
- Clinically significant medical or neurologic condition
- Diagnosis of primary comorbid anxiety disorder, defined by which disorder is the more debilitating and clinically salient
- History of bipolar disorder or schizophrenia
- Presence of an organic mental syndrome, mental retardation, or pervasive developmental disorder
- Current major depressive disorder or major depression within the past 6 months
- Hamilton Rating Scale for Depression score greater than 18
- Alcohol or drug abuse or dependence within the past year
- Current suicidal ideation
- Diagnosis of an Axis II personality disorder, except for avoidant personality disorder
- Treatments with psychotropic or psychoactive medications within the 2 weeks before screening (or 8 weeks for fluoxetine and 4 weeks for monoamine oxidase inhibitors)
- Positive urine drug screen results
- Pregnancy
- Additional exclusion criteria for the functional MRI studies:
- Left-handedness, as determined by standard questionnaire
- Presence of ferrous-containing metals within the body, such as aneurysm clips, shrapnel, or retained particles
- Claustrophobia
Key Trial Info
Start Date :
March 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2011
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00872131
Start Date
March 1 2008
End Date
August 1 2011
Last Update
November 23 2011
Active Locations (1)
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1
University of Michigan
Ann Arbor, Michigan, United States, 48109