Status:
WITHDRAWN
S0307A, Long-Term Bone Quality in Women With Breast Cancer Enrolled on Clinical Trial SWOG-S0307
Lead Sponsor:
SWOG Cancer Research Network
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Breast Cancer
Eligibility:
FEMALE
18+ years
Brief Summary
RATIONALE: Gathering information over time from imaging and laboratory tests of women receiving bisphosphonates for breast cancer may help doctors learn more about long-term bone quality and plan the ...
Detailed Description
OBJECTIVES: * To assess if long-term high-dose bisphosphonates alter bone quality as measured by change in the histomorphometry of bone biopsies after tetracycline hydrochloride labeling to calculate...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Concurrently enrolled on clinical trial SWOG-S0307 and receiving bisphosphonates as adjuvant therapy for primary breast cancer
- No rickets, osteogenesis imperfecta, osteosclerosis, or osteomalacia
- No bone fracture since the age of 21 years unless it was caused by trauma
- Hormone receptor status not specified
- PATIENT CHARACTERISTICS:
- Menopausal status not specified
- Weight \< 300 lbs
- No hyperparathyroidism
- No serious concurrent or prior anorexia nervosa diagnosed by a physician and causing abnormal menstruation
- No history of hypersensitivity to tetracycline or demeclocycline
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- More than 10 years since prior prednisone at a dose above 5 mg/day for ≥ 3 months
- No prior prednisone before diagnosis of breast cancer
- No prior bisphosphonate therapy
- No concurrent anticonvulsant medications
Exclusion
Key Trial Info
Start Date :
October 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2010
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00873808
Start Date
October 1 2008
End Date
February 1 2010
Last Update
April 10 2013
Active Locations (1)
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1
University Cancer Center at University of Washington Medical Center
Seattle, Washington, United States, 98195-6043