Status:
COMPLETED
Utility of Neutrophil Gelatinase-associated Lipocalin (NGAL) in Predicting Renal Impairment, Further Decompensation and Rehospitalization in Acutely Decompensated and Chronic Heart Failure Patients
Lead Sponsor:
The Alfred
Collaborating Sponsors:
Abbott RDx Cardiometabolic
Conditions:
Heart Failure
Eligibility:
All Genders
18+ years
Brief Summary
Acute decompensated heart failure (ADHF) is the leading cause of admission to hospital in the US, and is associated with high mortality, morbidity, and major cost to the health care system. Much of th...
Eligibility Criteria
Inclusion
- Males and Females
- Age \>18years
- Confirmed written informed consent
- Acute decompensated heart failure cohort defined as:
- Objective evidence of heart failure (of any cause/etiology) demonstrated by typical symptoms/signs combined with an imaging modality (see appendix for criteria)
- Requirement for intravenous diuretic whilst either an inpatient or in an emergency room setting with intravenous diuretics, vasodilators or inotropes
- No ejection fraction cut-off will be required, ie both systolic and diastolic heart failure patients can be enrolled
- Chronic Heart Failure cohort defined as:
- Echocardiographic evidence of systolic or diastolic heart failure (see appendix for criteria)
- CHF patients in Class III and class IV NYHA symptoms who have had a minimum of one acute decompensated episode in the previous six months
- Evidence of impaired renal function (eGFR \<60 ml/min)
Exclusion
- Patients with a history of a psychological illness or condition such as to interfere with the patient's ability to understand the requirements of the study
- Not meeting entry criteria for ADAF (as above)
- At the discretion of the treating physician
Key Trial Info
Start Date :
December 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2014
Estimated Enrollment :
106 Patients enrolled
Trial Details
Trial ID
NCT00874289
Start Date
December 1 2008
End Date
May 1 2014
Last Update
January 22 2015
Active Locations (1)
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1
Alfred Hospital
Melbourne, Victoria, Australia, 3004