Status:
COMPLETED
Effect of ACE-inhibitors on Aortic Stiffness in Elderly Patients With Chronic Kidney Disease
Lead Sponsor:
University of Wisconsin, Madison
Conditions:
Cardiovascular Disease
Chronic Kidney Disease
Eligibility:
All Genders
60-89 years
Phase:
PHASE2
Brief Summary
The goal of this proposal is to investigate the potential for ACE-inhibitors (ACE-I)(drugs primarily used to treat hypertension or congestive heart failure) to prevent or delay cardiovascular disease ...
Detailed Description
This study will be the first to examine whether aortic stiffness is increased in elderly patients with CKD compared to their age-matched healthy controls and further examine whether ACE-I may delay th...
Eligibility Criteria
Inclusion
- Age \> 60 years
- BP 120/80 or higher \*(bps will be checked weekly first 4 weeks to ensure \< 130/80 - IF bp remains \> 130/80 we will administer other bp meds per JNC VII guidelines)
- CKD stage 3 (GFR 30 - 59 ml/min) for CKD group; no CKD for control group
Exclusion
- Known significant CVD (history of Myocardial infarction (MI), recurrent stroke, or New York Heart Association (NYHA) class III or greater).
- Serum potassium \> 5.2 meq/L
- Known allergy or hypersensitivity to ACE inhibitor or ARB
- Female of childbearing age not practicing contraception
- Current treatment with an Angiotensin Converting Enzyme Inhibitors (ACE-I) or Angiotensin-Receptor Blockers (ARB) (Note: can participate if on ACE-I after 6 week washout period)
- History of ACE-I induced angioedema
- History of angioedema, hereditary or idiopathic
- Persons lacking consent capacity
- 500 mg/dL proteinuria on 2 consecutive spot urine protein/creat ratios
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
43 Patients enrolled
Trial Details
Trial ID
NCT00874432
Start Date
January 1 2009
End Date
December 1 2011
Last Update
October 27 2020
Active Locations (1)
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1
University of Wisconsin-Madison Hospitals and Clinics
Madison, Wisconsin, United States, 53792