Status:
TERMINATED
Imaginal Exposure & D-Cycloserine (DCS) for Posttraumatic Stress Disorder (PTSD)
Lead Sponsor:
Weill Medical College of Cornell University
Conditions:
Posttraumatic Stress Disorder
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
This study proposes to evaluate the effects of D-cycloserine (DCS) combined with cognitive-behavioral treatment with exposure therapy in a sample of patients who developed posttraumatic stress disorde...
Detailed Description
Following an initial assessment evaluating eligibility for the study, eligible participants will be randomly assigned to one of two treatment groups: imaginal exposure (IE) plus DCS (100mg) or IE plus...
Eligibility Criteria
Inclusion
- English-speaking adults
- Age 18-70
- Survivor of a variety of traumas (e.g., motor vehicle and accidents, burns and others injuries, combat, World Trade Center attack, etc.)
- Diagnosed with PTSD
- In good health. For persons with chronic injuries/conditions related to their accidents, "good health" is defined as the injury being in a state of stabilization and able to attend weekly outpatient sessions.
Exclusion
- Current organic mental disorder
- Schizophrenia or symptoms of psychosis/delusions
- Bipolar disorder
- Current substance abuse or dependence
- Active suicidal/homicidal ideation, intent, or plan
- Use of pacemaker
- Significant health impairment, including renal disease
- Taking oral anticoagulant medication, ethionamide (Trecator-SC), isoniazid (INH), or anti-depressant medication
- Hypersensitivity to cycloserine
- History of seizures
- Pregnant or currently trying to conceive, or breastfeeding
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 28 2018
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT00875342
Start Date
May 1 2008
End Date
February 28 2018
Last Update
August 16 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Weill Cornell Medical College
New York, New York, United States, 10065