Status:
COMPLETED
Optimizing Treatment of Post-hemorrhagic Ventricular Dilation in Preterm Infants
Lead Sponsor:
Washington University School of Medicine
Conditions:
Intraventricular Hemorrhage
Hydrocephalus
Eligibility:
All Genders
Up to 34 years
Phase:
NA
Brief Summary
Intraventricular hemorrhage remains the most frequent, severe neurological complication of prematurity, occurring in 25-30% of preterm infants. Post-hemorrhagic ventricular dilation (PHVD) occurs in 2...
Detailed Description
Cranial ultrasound (CUS) is routinely performed on preterm infants ≤ 34 weeks estimated gestational age (EGA) on day-of-life (DOL) #3 and again on DOL #7-10. Patients with Papile Grade II-IV intravent...
Eligibility Criteria
Inclusion
- Infants born at ≤ 34 weeks estimated gestational age with ultrasound-confirmed IVH will be followed for eligibility.
- All infants with any grade IVH will be carefully followed with serial ultrasounds 1-3 times weekly to monitor ventricular measures.
- All infants with any grade IVH will be carefully followed for their ventricular measures. If ventricular measures are crossing percentile lines toward the 90th then the infant will be considered for recruitment as soon as the measures cross 97th.
Exclusion
- Infants with congenital cerebral malformations
- Cystic periventricular leukomalacia
- CNS infection, metabolic disease
- PHVD present at birth will be excluded from the study.
Key Trial Info
Start Date :
May 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2013
Estimated Enrollment :
7 Patients enrolled
Trial Details
Trial ID
NCT00875758
Start Date
May 1 2009
End Date
November 1 2013
Last Update
November 6 2017
Active Locations (1)
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1
St. Louis Children's Hospital
St Louis, Missouri, United States, 63110