Status:
WITHDRAWN
International Registry for Primary Hyperoxaluria
Lead Sponsor:
Mayo Clinic
Collaborating Sponsors:
National Institutes of Health (NIH)
Oxalosis and Hyperoxaluria Foundation (OHF)
Conditions:
Primary Hyperoxaluria
Nephrocalcinosis
Eligibility:
All Genders
Brief Summary
The purpose of this study is to collect medical information from a large number of patients in many areas of the world with primary hyperoxaluria. This medical information will be entered into a regis...
Detailed Description
This study involves the collection of medical information to create a computer database (registry) for patients with PH. The information will be entered into the registry by your physician, healthcare...
Eligibility Criteria
Inclusion
- Liver biopsy or genetic analysis that confirms a diagnosis of hyperoxaluria
- In the absence of a liver biopsy:
- Urine oxalate excretion of \>0.8 mmol/1.73 m² /day without other causes such as enteric hyperoxaluria
- Family history of PH in a sibling will be supportive
- A history or current finding of kidney stones or nephrocalcinosis will be supportive
- An increase in urine glycolate may suggest PHI or an increase in urine L-glycerate may suggest PHII, though not required for diagnosis.
- Patients presenting in renal failure with an elevate pre-dialysis plasma oxalate of 60 umol/l and a kidney biopsy that confirms extensive oxalate deposition, or evidence of systemic oxalosis
Exclusion
- Patients without any of the above or a confirmed diagnosis of PH
Key Trial Info
Start Date :
September 1 2003
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2009
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00875823
Start Date
September 1 2003
End Date
July 1 2009
Last Update
April 7 2015
Active Locations (4)
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1
Mattel Children's Hospital at UCLA
Los Angeles, California, United States, 90095
2
University of California at Davis
Sacramento, California, United States, 95817
3
Children's Memorial Hospital
Chicago, Illinois, United States, 60614
4
Mayo Clinic Rochester
Rochester, Minnesota, United States, 55905