Status:
WITHDRAWN
Effects of Genotypes on Interferon Signaling in Chronic Hepatitis C
Lead Sponsor:
University of Nebraska
Conditions:
Chronic Hepatitis C
Eligibility:
All Genders
19+ years
Brief Summary
The objective of this pilot project is to investigate the prognostic criteria for sensitivity of Chronic Hepatitis C (CHC) Genotype 1, patients to IFNa treatment. Signal transduction in peripheral blo...
Detailed Description
In addition, the mechanism of non-responsiveness of HCV patients to IFNa will be studied. For this purpose, formation of complexes between STAT1 and its negative regulator, PIAS1 (immunoprecipitation,...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- 19 years of age or older, of either gender
- History of chronic hepatitis C documented by HCVRNA or healthy family member/significant other
- Documented genotype 1 for hepatitis participants or no hepatitis infection for healthy control
- Subject prescribed antiviral therapy for hepatitis participants or none for healthy control
- Able to give informed consent
- Exclusion Criteria
- Under 19 years of age
- Unable to give informed consent
Exclusion
Key Trial Info
Start Date :
April 15 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 8 2010
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00876174
Start Date
April 15 2009
End Date
January 8 2010
Last Update
August 16 2023
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