Status:
WITHDRAWN
Pharmacokinetics of Citalopram in Patients With Short Bowel Syndrome
Lead Sponsor:
University of Nebraska
Conditions:
Short Bowel Syndrome
Eligibility:
All Genders
19-65 years
Phase:
NA
Brief Summary
This study will look at how the body interacts with citalopram in adult participants with short bowel syndrome. While information on depression in patients with short bowel syndrome is sparse, the inv...
Detailed Description
This prospective study will determine the pharmacokinetic parameters of citalopram in 12 adult patients with short bowel syndrome. While data on the prevalence of depression in patients with short bow...
Eligibility Criteria
Inclusion
- Subjects must be between the ages 19-65 years.
- Subjects must have less than 200cm of functional small intestine.
- Subjects must be at least one month post bowel resection.
Exclusion
- Subjects less than 19 years or more than 65 years of age.
- Pregnant or breastfeeding women.
- Known hypersensitivity to citalopram or other SSRIs.
- Diagnosis of depression using MINI (Mini International Neuropsychiatric Interview).
- Ongoing antidepressant therapy.
- Evidence of cirrhosis (Child-Pugh stages B or C) or evidence of significant liver impairment defined as liver enzymes elevations greater that 2.5 times the upper limit of normal.
- Suicidal ideation.
- Bipolar disorder.
- Mania.
- Known history of seizures.
- Evidence of hyponatremia.
Key Trial Info
Start Date :
May 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 11 2012
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00876226
Start Date
May 1 2010
End Date
September 11 2012
Last Update
August 14 2023
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