Status:
COMPLETED
A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Tolerability of Oral Lixivaptan Capsules in Subjects With Euvolemic Hyponatremia
Lead Sponsor:
CardioKine Inc.
Collaborating Sponsors:
Cardiokine Biopharma, LLC
Biogen
Conditions:
Euvolemic Hyponatremia
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to evaluate the safety and tolerability of oral lixivaptan capsules in subjects with Euvolemic Hyponatremia.
Detailed Description
Phase I and Phase II clinical trials have demonstrated that lixivaptan may play an important role in treating hyponatremia and the signs and symptoms of water retention associated with HF, LCWA, and S...
Eligibility Criteria
Inclusion
- Written informed consent.
- Men or women aged 18 or older.
- Diagnosis of euvolemic hyponatremia (Na+ \< 135 mEq/L).
- Willing to be observed in a monitored setting for approximately the first 8 hours following treatment initiation (first dose).
- In the Investigator's judgement the patient has adequate visual and auditory acuity to allow participation in the trial.
Exclusion
- Pregnant or breast-feeding women, or women planning to become pregnant or to breastfeed.
- Overt symptoms of hyponatremia requiring immediate medical intervention (e.g., coma, seizures).
- Acute or transient hyponatremia (e.g., associated with head trauma, postoperative state, or use of radiotherapy and/or chemotherapy).
- Hyponatremia in hypovolemic states (e.g., due to fluid loss through vomiting, diarrhea, burns, etc.). Hypovolemic hyponatremia is defined as the presence of clinical evidence of extracellular fluid volume depletion.
- Hyponatremia in hypervolemic states (e.g., congestive heart failure). Hypervolemia is defined as a presence of increased total body water with signs of edema.
- Pseudohyponatremia (i.e., hyponatremia resulting from a laboratory artifact).
- Hypertonic hyponatremia (e.g., hyponatremia in the setting of hyperglycemia).
- Hyponatremia as a result of any medication that can safely be withdrawn.
- Hyponatremia due to hypothyroidism or adrenal insufficiency.
- Current diagnosis of psychogenic polydipsia.
- Receiving within 7 days of enrollment other medication for treatment of hyponatremia, specifically: demeclocycline, lithium carbonate, urea, or any vasopressin antagonist.
- Supine systolic arterial blood pressure of ≤ 90 millimeters of mercury (mmHg).
- Serum creatinine \> 3.0 mg/dL (\> 265.2 mol/L).
- Hypokalemia based on clinical sign/symptoms or lab findings (e.g., serum potassium \< 3.5 mEq/L).
- Uncontrolled diabetes mellitus as defined by the Investigators (e.g., hemoglobin - glycosylated \[HbA1c\] \> 9%).
- ST-segment elevation myocardial infarction (STEMI) within 30 days or active myocardial ischemia at the time of enrollment.
- History of cerebral vascular accident (CVA) within 30 days prior to screening.
- Severe malnutrition in the Investigator's judgment (e.g., body mass index \[BMI\] \< 17).
- Advanced liver disease or documented diagnosis of cirrhosis or alcoholic hepatitis.
- Urinary tract obstruction (benign prostatic hypertrophy \[BPH\] allowed if non-obstructive).
- History of chronic drug/medication abuse within the past 6 months or current alcohol abuse.
- Terminally ill or moribund condition with little chance of short-term survival.
- Receiving vasopressin or its analogs for treatment of any condition.
- Known allergy to any vasopressin antagonist.
- Previous participation in a lixivaptan study.
- Recipient of any investigational treatment within 30 days prior to baseline visit.
- Unable to take oral medications.
- Significant neurological disorders (e.g., permanent neurological deficits, probable Alzheimer's disease, normal pressure hydrocephalus, Parkinsonian dementia complex, multi-infarct dementia, mixed dementia, or Huntington's disease).
- Conditions limiting access to water or an inability to respond to thirst (e.g., hydrophobia, or non-communicative).
Key Trial Info
Start Date :
June 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
206 Patients enrolled
Trial Details
Trial ID
NCT00876798
Start Date
June 1 2009
Last Update
June 28 2011
Active Locations (90)
Enter a location and click search to find clinical trials sorted by distance.
1
Birmingham Nursing and Rehabilitation East
Birmingham, Alabama, United States, 35205
2
Healthscan Research, LLC
Montgomery, Alabama, United States, 36109
3
PsyPharma Clinical Research, Inc.
Phoenix, Arizona, United States, 85050
4
PsyPharma Clinical Research
Phoenix, Arizona, United States, 85050