Status:
COMPLETED
Obstructive Sleep Apnea and Diabetes Mellitus
Lead Sponsor:
The University of Hong Kong
Conditions:
Obstructive Sleep Apnea
Diabetes Mellitus
Eligibility:
All Genders
25-70 years
Phase:
NA
Brief Summary
The investigators hypothesize that obstructive sleep apnea (OSA) contributes to impaired glucose homeostasis and associated vasculopathy, and nCPAP treatment of OSA should improve glycemic control and...
Detailed Description
Obstructive sleep apnoea (OSA) has been reported to be common (17%) in patients with diabetes mellitus (DM). Both OSA and DM are highly associated with cardiovascular morbidity and mortality. There is...
Eligibility Criteria
Inclusion
- Patients with type II DM on a stable medication regimen (on diet / oral hypoglycaemic agents / insulin injections)
- Age 25 - 70 years
- HbA1C \> 7%
- AHI \>= 15
- Able to give written informed consent
Exclusion
- Patients with severe co-existing illness or poor functional performance
- Patients with peripheral vascular diseases, vasculitis / Raynaud's syndrome or thrombocytopenia
- Sleep disorders other than OSA
- Patients who refuse nCPAP treatment for OSA
- Excessive sleepiness causing potential harm (e.g. driver)
- HbA1C \>=7%
- Habitual drinker (defined as more than 3 times a week)
- Pregnant or lactating women
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2012
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT00876980
Start Date
May 1 2008
End Date
February 1 2012
Last Update
October 16 2013
Active Locations (1)
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1
Queen Mary Hospital, University Department of Medicine
Pokfulam, Hong Kong, Hong Kong, 0000