Status:
COMPLETED
Routine Versus Aggressive Upstream Rhythm Control for Prevention of Early Atrial Fibrillation in Heart Failure
Lead Sponsor:
I.C. Van Gelder
Collaborating Sponsors:
The Interuniversity Cardiology Institute of the Netherlands
Netherlands Heart Foundation
Conditions:
Atrial Fibrillation
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
The purpose of this study is to investigate whether in patients with early persistent atrial fibrillation and mild to moderate early heart failure an aggressive upstream rhythm control approach, inclu...
Eligibility Criteria
Inclusion
- Early symptomatic persistent atrial fibrillation
- Mild to moderate early heart failure
- Optimal documentation and treatment of underlying heart disease
- No contra-indication for oral anticoagulation
- Eligible for cardiovascular rehabilitation
- Age \>= 40 years
Exclusion
- On waiting list for pulmonary vein isolation or expected to be placed on waiting list within one year
- Heart failure NYHA class IV
- LVEF \< 25%
- Left atrial size \> 50 mm (parasternal axis)
- Present aldosterone receptor antagonist use
- Previous use of class I or III antiarrhythmic drugs (except for sotalol, which should be discontinued at inclusion and replaced with betablocker)
- Cardiac resynchronization therapy
Key Trial Info
Start Date :
May 4 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 31 2021
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT00877643
Start Date
May 4 2009
End Date
January 31 2021
Last Update
August 19 2021
Active Locations (20)
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1
Ziekenhuisgroep Twente
Almelo, Netherlands
2
Onze Lieve Vrouwe Gasthuis
Amsterdam, Netherlands
3
Hospital Rijnstate
Arnhem, Netherlands
4
Ter Gooi Hospital
Blaricum, Netherlands