Status:
COMPLETED
Effects of a Surgery-induced Peripheral Inflammatory Response on the Blood Brain Barrier
Lead Sponsor:
Nova Scotia Health Authority
Collaborating Sponsors:
Dalhousie University
Conditions:
Dissecting Aneurysm of the Thoracic Aorta
Eligibility:
All Genders
Phase:
PHASE4
Brief Summary
The purpose for this study is to determine if surgery (repair of descending thoracic aneurysm) causes a temporary decrease in the Blood Brain Barrier's ability to remove drugs from the brain back into...
Detailed Description
Study Objectives: To determine the role of surgery-induced inflammation on the transport of morphine and its metabolites, M3G and M6G, across the blood-brain barrier. Study phase: IV Study Design: Th...
Eligibility Criteria
Inclusion
- Subjects who are to undergo elective surgery for thoracic aortic vascular disease requiring insertion of a lumbar CSF drain
- Informed consent will be obtained from the subject or authorized legal representative -
Exclusion
- Unwilling or unable to provide informed consent
- Sensitivity or documented allergy to morphine
- Inability to place lumbar CSF drain
- Dialysis dependent -
Key Trial Info
Start Date :
May 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2013
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT00878371
Start Date
May 1 2009
End Date
February 1 2013
Last Update
June 23 2016
Active Locations (1)
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1
Capital Health- Queen Elizabeth II Health Sciences Centre
Halifax, Nova Scotia, Canada, B3H3A7