Status:
COMPLETED
Memantine in the Treatment of Kleptomania
Lead Sponsor:
University of Chicago
Conditions:
Kleptomania
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
The goal of the proposed study is to evaluate the efficacy and safety of memantine in kleptomania.
Detailed Description
The proposed study will consist of 8 weeks of treatment with memantine in 10 subjects with kleptomania. The hypothesis to be tested is that memantine will be effective in reducing the urges to steal i...
Eligibility Criteria
Inclusion
- men and women age 18-65
- current KM using the clinician-administered Structured Clinical Interview for Kleptomania (SCI-K)
- stealing behavior within 2 weeks prior to enrollment.
Exclusion
- infrequent stealing (i.e. less than one time per week) that does not meet proposed criteria for kleptomania (KM)
- unstable medical illness or clinically significant abnormalities on laboratory tests or physical examination at screen
- history of seizures
- myocardial infarction within 6 months
- current pregnancy or lactation, or inadequate contraception in women of childbearing potential
- a need for medication other than memantine with possible psychotropic effects or unfavorable interactions
- clinically significant suicidality
- current Axis I disorder determined by the Structured Clinical Interview for the DSM (SCID) and SCID-compatible modules for impulse control disorders (Grant et al., 2005), except for nicotine dependence
- lifetime history of bipolar disorder type I or II, dementia, schizophrenia, or any psychotic disorder determined by SCID
- current or recent (past 3 months) DSM-IV substance abuse or dependence
- positive urine drug screen at screening
- initiation of psychotherapy or behavior therapy within 3 months prior to study baseline
- previous treatment with memantine; and 14) treatment with investigational medication or depot neuroleptics within 3 months, with fluoxetine within 6 weeks, or with other psychotropics within 2 weeks prior to study baseline.
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2012
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00880685
Start Date
March 1 2009
End Date
June 1 2012
Last Update
May 24 2021
Active Locations (1)
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1
University of Minnesota
Minneapolis, Minnesota, United States, 55454