Status:
COMPLETED
Safety of MP470 in Combination With Standard-of-Care Chemotherapy Regimens to Treat Solid Tumors
Lead Sponsor:
Astex Pharmaceuticals, Inc.
Conditions:
Malignant Disease
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Adult subjects with malignant disease appropriate for treatment with carboplatin/paclitaxel, carboplatin/etoposide, topotecan, docetaxel or erlotinib according to the standard dosing regimen will be e...
Eligibility Criteria
Inclusion
- Malignant disease appropriate for initiating treatment with carboplatin/paclitaxel, carboplatin/etoposide, topotecan, docetaxel, or erlotinib.
- Must be able to read, understand, and sign the IRB approved Informed Consent Form.
- At least 18 years old.
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
- Adequate bone marrow function; normal renal and hepatic function, normal cardiac function.
Exclusion
- Any other active invasive malignancy except non-melanoma skin cancers or cervical carcinoma in situ.
- History of significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias, congestive heart failure and/or myocardial infarction.
- Received any anticancer agent(s) within the past 3 weeks, including investigational agents, chemotherapy (6 weeks for nitrosoureas or mitomycin), immunotherapy, biologic or hormonal therapy other than LHRH agonists.
- Received prior radiation therapy within the past 4 weeks.
- Any serious, uncontrolled active infection that requires systemic treatment or known infection with HIV, HCV or HBV.
- Patient requires treatment with immunosuppressive agents other than corticosteroids appropriate for the SOC chemotherapy regimen or those at stable doses for at least 2 weeks.
Key Trial Info
Start Date :
November 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2009
Estimated Enrollment :
101 Patients enrolled
Trial Details
Trial ID
NCT00881166
Start Date
November 1 2007
End Date
December 1 2009
Last Update
August 2 2024
Active Locations (5)
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1
Premiere Oncology
Scottsdale, Arizona, United States, 85258
2
Premiere Oncology
Santa Monica, California, United States, 90404
3
Audie Murphy Veterans Memorial Hospital (VA)
San Antonio, Texas, United States, 78229
4
CTRC at the UT Health Science Center at San Antonio
San Antonio, Texas, United States, 78229