Status:
COMPLETED
Effect of Continuous Positive Airway Pressure for Treatment of Obstructive Sleep Apnea on Resistant Hypertension
Lead Sponsor:
The University of Hong Kong
Conditions:
Resistant Hypertension
Obstructive Sleep Apnea
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The objectives of this study are to investigate the effect of continuous positive airway pressure (CPAP) treatment on blood pressure control and vascular inflammation in subjects with resistant hypert...
Detailed Description
Resistant hypertension is defined as blood pressure that remains above goal in spite of concurrent use of 3 antihypertensive agents of different classes. Resistant hypertension is defined in order to ...
Eligibility Criteria
Inclusion
- Age 18 - 65
- known hypertension on ≧ 3 anti-hypertensive drugs
- Apnea-hypopnea index ≧15
- able to give informed written consent
Exclusion
- moderate renal impairment (glomerular filtration rate \<30 mL/min/m2 )
- endocrine/renal/cardiac causes of secondary HT
- congestive heart failure and clinically fluid overloaded
- On drugs that elevates BP e.g. NSAID, steroid
- Non-compliance to anti-hypertensive medications
- Unstable medical conditions such as unstable angina, recent myocardial infarction/stroke within 3 months
- Active inflammatory/infective conditions e.g. rheumatoid arthritis
- Excessive sleepiness that can be risky e.g. occupational driver, machine operator
- Modification/changes of anti-hypertensive regimen within 8 weeks
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2019
Estimated Enrollment :
92 Patients enrolled
Trial Details
Trial ID
NCT00881985
Start Date
March 1 2009
End Date
July 1 2019
Last Update
October 2 2019
Active Locations (1)
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1
Queen Mary Hospital
Hong Kong, China, 852