Status:
COMPLETED
Broccoli Sprout Extract Effects on Allergic Inflammation in the Nose
Lead Sponsor:
University of California, Los Angeles
Conditions:
Allergic Airway Disease
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Allergic airway disease is a term used to describe conditions such as allergic rhinitis and asthma. Among other causative agents, air pollutants and diesel exhaust in particular, have been shown to cr...
Detailed Description
Antioxidant enzymes are proteins produced by the body to protect cells against the harmful effects of chemicals, such as those found in air pollution. Particulate air pollution and diesel exhaust in p...
Eligibility Criteria
Inclusion
- Able and willing to provide informed consent
- DEP responder as defined in protocol
- Ability to refrain from consuming cruciferous vegetables 3 days prior to starting study and while on study. Cruciferous vegetables include: Broccoli, Kale, Chard, Kohlrabi, Brussels Sprouts, Parsley, Watercress, Daikon, Cabbage, Rutabagas, Cauliflower, Bok Choy, Arugula, Turnips, Radish, Mustard and Collard greens.
- Allergy skin test positive to cat
- Nonsmoker or ex-smoker of more than one year
Exclusion
- Smoking within past year or during study
- Systemic corticosteroid or other immunosuppressive medication use in the previous 3 months or during study
- Intranasal corticosteroid use in the previous month or during the study
- Intranasal antihistamine or cromolyn use in the previous week or during study
- Allergen immunotherapy during the previous 12 months or during study
- Omalizumab use in the previous 12 months or during study
- Systemic antihistamine or leukotriene modifying medication use in the previous week or during study
- History of asthma or any current medical condition that in the opinion of the investigator may compromise the subject's ability to safely participate in the study
- Baseline abnormality of hemoglobin, platelets, leukocytes, serum chemistries, liver function testing, or presence of proteinuria
- A finding during physical examination that, in the opinion of the investigator may compromise the participant's ability to safely participate in the study
- Pregnant or breast-feeding
Key Trial Info
Start Date :
July 10 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT00882115
Start Date
July 10 2009
End Date
December 1 2011
Last Update
September 20 2019
Active Locations (1)
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1
UCLA
Los Angeles, California, United States, 90095