Status:
COMPLETED
Granzymes and Perforin at the Onset of Chronic Obstructive Pulmonary Disease (COPD) Exacerbations
Lead Sponsor:
University of Thessaly
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
18-90 years
Brief Summary
COPD exacerbations are characterized by an excessive accumulation and activation of inflammatory cells in the airways. It is not known whether this phenomenon represents a risk for for lung damage via...
Detailed Description
The course of Chronic Obstructive Pulmonary Disease (COPD) is characterized by exacerbations which lead to significant clinical deterioration and morbidity.COPD exacerbations are characterized by an a...
Eligibility Criteria
Inclusion
- COPD patients
- All COPD patients who seek medical assistance at the clinic during the study period will be asked about COPD exacerbation related symptoms-medical history and then they will be included in the study if they satisfied all the following criteria:
- COPD diagnosis according to the GOLD Consensus Statement
- initiation of symptoms diagnostic for COPD exacerbation in the past 72 hours
- abstention from any new therapeutic intervention
- absence of any signs suggestive of severe exacerbation requiring hospitalization
- Control subjects
- Subjects who seek medical assistance at respiratory clinic for symptoms suggesting acute bronchitis (dyspnea, sputum production, purulence, wheeze, cough)
- medical history free of COPD, Asthma, pneumonia, other chronic respiratory disease or congestive cardiac failure,
- initiation of symptoms in the past 72 hours,
- abstention from any new therapeutic intervention, and
- absence of any signs suggestive of clinical condition requiring hospitalization.
Exclusion
- Patients with Asthma or other respiratory disease will be excluded from this study
Key Trial Info
Start Date :
December 1 2002
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2009
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00883701
Start Date
December 1 2002
End Date
September 1 2009
Last Update
April 29 2010
Active Locations (1)
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1
University Hospital Larisa
Larissa, Thessaly, Greece