Status:
ACTIVE_NOT_RECRUITING
The Northern-European Initiative on Colorectal Cancer
Lead Sponsor:
Oslo University Hospital
Collaborating Sponsors:
Maria Sklodowska-Curie National Research Institute of Oncology
Erasmus Medical Center
Conditions:
Colorectal Cancer
Eligibility:
All Genders
55-64 years
Phase:
PHASE3
Brief Summary
Colorectal cancer (CRC) is a major burden in western countries. The disease develops from precursor lesions during a long time-interval. Colonoscopy can detect and remove CRC precursor lesions and may...
Eligibility Criteria
Inclusion
- This study is a population-based randomised controlled trial, with randomisation of individuals age 55-64 years living in the screening areas directly from the Population Registries to either screening group or control group. Eligible persons with the same home address will be randomised to the same group (household randomisation).
Exclusion
- Individuals with previous colorectal surgery (resections, enterostomies)
- Individuals in need of long-lasting attention and nursing services (somatic or psychosocial, mental retardation).
- On-going cytotoxic treatment or radiotherapy for malignant disease
- Severe chronic (longer than trial duration) cardiac (NYHA III-IV)or lung disease
- Lifelong anticoagulant therapy with Warfarin
- A coronary event requiring hospitalization during the last 3 months
- A cerebrovascular event during the last 3 months
- Resident abroad
- Return of unopened letter of invitation and/or reminder (address unknown)
- Message from neighbour/family/post office on death of screenee (not updated in Population Registry)
Key Trial Info
Start Date :
May 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2036
Estimated Enrollment :
95000 Patients enrolled
Trial Details
Trial ID
NCT00883792
Start Date
May 1 2009
End Date
July 1 2036
Last Update
June 19 2017
Active Locations (7)
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1
Harvard School of Public Health
Boston, Massachusetts, United States
2
Memorial Sloan-Kettering Cancer Center
New York, New York, United States
3
Landspitali University Hospital
Reykjavik, Iceland
4
Erasmus University Medical Center
Rotterdam, Netherlands