Status:
COMPLETED
Emergence Delirium in Children: Total Intravenous Anesthesia With Propofol and Remifentanil Versus Inhalational Sevoflurane Anesthesia
Lead Sponsor:
University of British Columbia
Conditions:
Emergence Delirium
Eligibility:
All Genders
2-6 years
Phase:
NA
Brief Summary
Emergence delirium (ED) refers to a wide variety of behavioural disturbances that are commonly seen in children following emergence from anesthesia. ED can potentially be dangerous and have serious co...
Detailed Description
Purpose: In children, both propofol-only anesthesia maintenance infusions and single postoperative propofol boluses have been shown to be efficacious at reducing ED when compared with sevoflurane onl...
Eligibility Criteria
Inclusion
- Children having general anesthesia for elective strabismus or other suitable minor eye surgery
- Age ≥ 2 and ≤ 6 years
- ASA I-II
- Appropriate procedure and patient for LMA airway management
Exclusion
- Developmental delay or neurological injury
- Psychotropic medications or psychiatric diagnosis
- Abnormal lipid or carbohydrate metabolism
- Deviations from the anesthesia protocol including an inability to secure pre-anesthetic intravenous access in the TIVA group
- Severe anxiety in the pre-operative period requiring sedative. premedication according to the staff anesthesiologist's and family's assessment
- Patients experiencing pain requiring analgesia, postoperative nausea or vomiting (PONV) during the study period
- Patients seen in the pre-anesthetic assessment clinic, due to habituation to hospital environment
- Growth chart percentiles of \< 3% or \> 97%
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2011
Estimated Enrollment :
112 Patients enrolled
Trial Details
Trial ID
NCT00885443
Start Date
February 1 2009
End Date
August 1 2011
Last Update
July 5 2017
Active Locations (1)
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1
British Columbia Children's Hospital
Vancouver, British Columbia, Canada, V6H 3V4