Status:
UNKNOWN
Ability of Metoprolol to Alter the Exercise Induced Elevation of Catecholamines
Lead Sponsor:
Rigshospitalet, Denmark
Collaborating Sponsors:
Danish Heart Foundation
Conditions:
Heart Failure
Eligibility:
MALE
18-30 years
Phase:
PHASE4
Brief Summary
Heart failure is a frequent disease in Denmark, and it is associated with very high mortality. Around 60,000 people in Denmark have heart failure, and there is about 11,000 hospitalizations every year...
Eligibility Criteria
Inclusion
- Kaukaser
- Healthy men
- 18 years \< age \< 30 years
- Non-smoker
- 18 \< BMI \< 25
- No chronic diseases
- Motor-disability that disables completement of cardio-pulmonary exercise-test.
Exclusion
- Alcohol abuse or any other abuse
- Intake of any narcotic drugs (example: cannabinoids, narcotics, stimulants of central nervous system, hypnotics, hallucinogenes)
- Any of following medication:
- astmamedication
- heartmedication
- antihistamines
- antipsycotics
- NSAIDs
- rifampicine
- chinidine
- glucocorticoids
- Abnormal ECG, particularly 2. or 3. degree AV-block, sinusbradycardia, sick sinusnode-syndrome, sign of heart failure or ischemia.
- Allergy or intolerance of metoprolole
- Lactoseallergy
- 110 mmHg \< Systolic blood pressure \< 140 mmHg
- 60 mmHg \< Diastolic blood pressure \< 90 mmHg
- Bloodsucker \> 11,1 mmol/L, or fasting, venous bloodsucker \>= 7,0 (measured if: 7,8 \< BS \< 11,1)
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2009
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00885651
Start Date
September 1 2008
End Date
December 1 2009
Last Update
April 22 2009
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