Status:
COMPLETED
Omega-3 Fatty Acids, the Omega-3 Index, and Atherosclerosis
Lead Sponsor:
Ludwig-Maximilians - University of Munich
Conditions:
Atherosclerosis
Eligibility:
All Genders
30-75 years
Phase:
NA
Brief Summary
An increase in intake of omega-3 fatty acids should increase the Omega-3 Index. Current evidence indicates that this may lead to a reduction in risk for sudden cardiac death and atherosclerotic diseas...
Eligibility Criteria
Inclusion
- Subjects must meet the current guideline criteria for atherosclerosis, like coronary, peripheral or carotid artery disease, like previous myocardial infarction or acute coronary syndrome, coronary revascularization (operation or transluminally), or positive angiography or ultrasound.
- Age: 30 - 75 years
- Low Omega-3 Index (\<5%)
- Subjects must have adequate fluency in German or English to complete baseline and follow-up interviews.
- Stable intake of food containing EPA+DHA before and during study
- Subjects must be able and willing to give written informed consent, and to comply with study procedures.
Exclusion
- Subjects for whom the intake of omega-3 fatty acids is mandatory according to recent treatment guidelines or who take omega-3 fatty acids supplements on a regular basis.
- Patients consuming \>2 portions of fatty fish / week
- Patients with serious bleeding disorder. Use of platelet inhibitors or anticoagulation with a target INR of 2.0 - 3.0 is not an exclusion criterion.
- Subjects with any acute and life-threatening condition, such as collapse and shock, acute myocardial infarction (last three months), stroke, embolism.
- Subjects with significant medical co-morbidity, seriously limiting life expectancy or insulin-treated diabetes mellitis or a BMI\>30
- Allergy/intolerance or history of hypersensitivity to components of study intervention, like lactose.
- Pregnant subjects - due to any possible teratogenic effects of study nutrition on the fetus - and breastfeeding subjects. In addition, women of childbearing potential who will not practice a medically accepted method of contraception will be excluded.
- Subjects who, in the investigator's judgement, will not likely be able to comply with the study protocol or with known drug- or alcohol abuse/dependence in the past 2 years.
- Use of any investigational agents within 30 days prior to t0
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2009
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00886704
Start Date
April 1 2009
End Date
September 1 2009
Last Update
October 7 2011
Active Locations (1)
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1
Preventive Cardiology
Munich, Germany, 80336