Status:
COMPLETED
Metabolic Effects of Antihypertensive Drugs on People With Metabolic Syndrome (The MEAD Study)
Lead Sponsor:
University of Florida
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Hypertension
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
High blood pressure, also referred to as hypertension, is a blood pressure level of 140/90 mm Hg or higher. Along with lifestyle changes, various medications are currently used to treat people with hy...
Detailed Description
Treatment for hypertension includes lifestyle changes and medications. Examples of some antihypertensive medications include diuretics, beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, a...
Eligibility Criteria
Inclusion
- Hypertension, defined as systolic blood pressure greater than or equal to 130 but less than 160 mm Hg and diastolic blood pressure greater than or equal to 85 but less than 110 mm Hg
- Must have any two of the following criteria:
- Abdominal obesity, defined as a waist circumference greater than 40 inches in men and greater than 35 inches in women
- High-density lipoprotein (HDL) cholesterol level of less than 40 mg/dL in men and less than 50 mg/dL in women
- Fasting triglycerides greater than or equal to 150 mg/dL
- Fasting glucose level of 100-125 mg/dL
Exclusion
- Significant hypertension (greater than 160/110 mm Hg)
- Isolated systolic hypertension
- Diseases requiring treatment with diuretics or angiotensin-converting enzyme (ACE) inhibitors
- Cardiovascular disease (history of heart attack, stroke, heart failure)
- Hypersensitivity to HCTZ or ACE inhibitor
- Type 1 or type 2 diabetes
- Hypokalemia
- Peri-menopause (symptom onset within 1 year)
- Pregnant or breastfeeding
- Secondary causes of hypertension
- Current use of antihypertensive medications known to affect glucose homeostasis (e.g., diuretics, beta blockers, corticosteroids, ACE inhibitors, angiotensin receptor blockers \[ARBs\])
Key Trial Info
Start Date :
May 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2009
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00887510
Start Date
May 1 2007
End Date
November 1 2009
Last Update
June 17 2014
Active Locations (1)
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1
University of Florida
Gainesville, Florida, United States, 32610