Status:
COMPLETED
Sodium Bicarbonate Supplementation in Chronic Kidney Disease Evaluation of Dose Response, Safety and Beneficial Effects
Lead Sponsor:
Albert Einstein College of Medicine
Conditions:
Chronic Kidney Disease
Eligibility:
All Genders
21+ years
Phase:
PHASE2
PHASE3
Brief Summary
This study will enroll 25 patients with kidney disease to evaluate the effects of different doses of sodium bicarbonate (baking soda) on levels of bicarbonate in the blood, kidney function and muscle ...
Detailed Description
This study enrolled 20 patient to evaluate the effects of different doses of sodium bicarbonate. We will test serum bicarbonate levels, potassium levels and muscle function.
Eligibility Criteria
Inclusion
- Estimated GFR \< 45 ml/min/1.73m2 and \>15 ml/min/1.73 m2 determined by abbreviated 4 variable modification MDRD equation
- Age \>21
Exclusion
- Previous chronic treatment with alkali (including sodium bicarbonate, calcium carbonate or baking soda)
- Bicarbonate level \<20 or \>25 mEq/L
- Decompensated heart failure
- Systolic blood pressure \>160 mm/Hg
- Moderate or greater lower extremity edema
- Initiation of ESRD treatment planned within 6 months
- Kidney transplantation
- Treatment with immunosuppressives within the last 3 months
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2010
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00888290
Start Date
March 1 2009
End Date
May 1 2010
Last Update
August 30 2022
Active Locations (1)
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1
Albert Einstein College of Medicine/ Montefiore Medical Center
The Bronx, New York, United States, 10461