Status:
COMPLETED
Iron Overload in Patients Undergoing Donor Stem Cell Transplant
Lead Sponsor:
Masonic Cancer Center, University of Minnesota
Conditions:
Cancer
Hematopoietic Stem Cell Transplantation
Eligibility:
All Genders
18-75 years
Brief Summary
RATIONALE: Learning about the effect of excess iron in the liver of patients undergoing donor stem cell transplant may help doctors plan treatment. PURPOSE: This study is investigating the effects of...
Detailed Description
OBJECTIVES: Primary * Determine the impact of pre-transplant iron overload (defined as liver iron concentration \[LIC\] above normal \[\> 1.8 mg/g\] on an MRI of the liver measuring tissue proton tr...
Eligibility Criteria
Inclusion
- Planning to undergo allogeneic hematopoietic stem cell transplantation using either myeloablative or reduced-intensity conditioning
- Any diagnosis allowed
- Not pregnant
- Weight ≤ 350 lbs
- Must be able to give written informed consent indicating the investigational nature of the study and its potential risks.
Exclusion
- Claustrophobia
- Other contraindication for MRI (e.g., cardiac pacemaker, implanted cardiac defibrillator, aneurysm clips, carotid artery vascular clamp, neurostimulator, insulin or infusion pump, or implanted drug infusion device)
Key Trial Info
Start Date :
December 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2012
Estimated Enrollment :
112 Patients enrolled
Trial Details
Trial ID
NCT00888316
Start Date
December 1 2008
End Date
June 1 2012
Last Update
December 2 2017
Active Locations (1)
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1
University of Minnesota Children's Hospital - Fairview
Minneapolis, Minnesota, United States, 55455