Status:
COMPLETED
Screening Evaluation for Studies of Chronic Obstructive Pulmonary Disease (COPD)
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
40-100 years
Brief Summary
This research is being done to study mechanisms of progression of COPD and to develop treatments for it. The investigators are doing the present study to identify people age 40 and older with mild to ...
Detailed Description
This is a program to recruit and screen participants for clinical trials or more detailed observational studies of COPD. There are no interventions or comparative results to be published from this stu...
Eligibility Criteria
Inclusion
- Age 40 years and older, either sex
- Mild to moderate COPD (FEV1/Forced vital capacity (FVC) ratio ≤ 0.70, FEV1 30-70% predicted, Diffusing capacity of the lungs for carbon monoxide (DLCO) ≥35% predicted)
- On stable maintenance therapy for 2 months
- Current or former smoker (patient report of at least a 10 pack-year history)
- Ability to understand and willingness to sign consent documents
Exclusion
- COPD exacerbation requiring treatment within past 6 weeks
- Untreated arterial hypertension (systolic blood pressure \> 140 mm Hg, diastolic blood pressure \> 90 mm Hg)
- Decompensated heart failure
- Myocardial infarction within past 3 months or ever
- Evidence of interstitial, occupational or chronic infectious lung disease
- Renal dysfunction
- Supplemental oxygen \> 2 liters/m at rest
- Failure to keep screening appointments
Key Trial Info
Start Date :
January 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2017
Estimated Enrollment :
670 Patients enrolled
Trial Details
Trial ID
NCT00889447
Start Date
January 1 2008
End Date
May 1 2017
Last Update
March 12 2018
Active Locations (1)
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1
Johns Hopkins Asthma and Allergy Center
Baltimore, Maryland, United States, 21224