Status:
COMPLETED
Stress Resilience Study
Lead Sponsor:
Kronos Longevity Research Institute
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Oxidative Stress
Aging
Eligibility:
All Genders
60-80 years
Brief Summary
The purpose of this study is to test the hypothesis that physiological adaptations to regular exercise training (i.e. physical fitness) attenuates age-related decline in stress resilience to both oxid...
Detailed Description
Aging is associated with diminished stress resilience, as in reduced ability to manage or recover from acute changes in homeostasis. Increased oxidative damage to cells and tissues and dysregulation o...
Eligibility Criteria
Inclusion
- Men and post-menopausal women, ages 60-80 years
- Generally good health by self-report
Exclusion
- Estrogen or testosterone supplementation within the previous 6 months
- Current smoker
- Body Mass Index (BMI) \> 32 kg/m2
- Any chronic illness that could affect cortisol levels, including diabetes mellitus, liver or renal disease
- Evidence of a previous myocardial infarction within the last 6 months by EKG or history of angina or shortness of breath
- Clinically significant arrhythmia on a resting EKG or significant EKG changes during the baseline VO2max test
- Any other condition that would contraindicate maximal exercise testing, including elevated blood pressure at rest (systolic BP \>140 or diastolic BP \>90 mm Hg on at least 2 measurements, at least 10 minutes apart) or musculoskeletal problems
- Depression as measured by the Beck Depression Inventory (BDI score \>17)
- Use of anti-oxidant supplements, in excess of standard multi-vitamins (1 tablet/day)
Key Trial Info
Start Date :
July 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2010
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00891488
Start Date
July 1 2008
End Date
May 1 2010
Last Update
August 3 2010
Active Locations (1)
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1
Kronos Longevity Research Institute
Phoenix, Arizona, United States, 85016