Status:
COMPLETED
Nutritional and Contractile Regulation of Muscle Growth
Lead Sponsor:
The University of Texas Medical Branch, Galveston
Collaborating Sponsors:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Conditions:
Sarcopenia
Eligibility:
All Genders
18-85 years
Phase:
PHASE1
Brief Summary
Muscle wasting, which involves the loss of muscle tissue, is common in many conditions, such as cancer, AIDS, trauma, kidney failure, bone fracture, and sepsis. It is also prevalent among the elderly ...
Detailed Description
Skeletal muscle comprises about 40% of one's body weight and contains about 50% to 75% of all the proteins in the human body. The turnover of protein is a regular process in the human body. In healthy...
Eligibility Criteria
Inclusion
- 18 to 35 years of age for the young groups
- 60 to 85 years of age for the older groups
- In the follicular phase for the young women participants
- Ability to sign consent form, as based on a score of greater than 25 on the 30-item Mini Mental State Examination (MMSE)
- Stable body weight for at least 1 year
Exclusion
- Physical dependence or frailty, as determined by impairment in any of the activities of daily living (ADLs), history of more than two falls per year, or significant weight loss in the past year
- Exercise training that consists of more than two weekly sessions of moderate to high intensity aerobic or resistance exercise
- Significant heart, liver, kidney, blood, or respiratory disease
- Peripheral vascular disease
- Diabetes mellitus or other untreated endocrine disease
- Active cancer
- History of cancer for participants who may be randomly assigned to rapamycin)
- Acute infectious disease or history of chronic infections (e.g., tuberculosis, hepatitis, HIV, herpes)
- Treatment with anabolic steroids or corticosteroids within 6 months of study entry
- Alcohol or drug abuse
- Tobacco use (smoking or chewing)
- Malnutrition (e.g., body mass index \[BMI\] less than 20 kg/m2, hypoalbuminemia, and/or hypotransferrinemia)
- Obesity (BMI greater than 30 kg/m2)
- Lower than normal hemoglobin levels
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2015
Estimated Enrollment :
144 Patients enrolled
Trial Details
Trial ID
NCT00891696
Start Date
April 1 2009
End Date
March 1 2015
Last Update
May 4 2017
Active Locations (1)
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1
Department of Nutrition & Metabolism, University of Texas Medical Branch
Galveston, Texas, United States, 77550