Status:
COMPLETED
A Study of the Effect of Carbamazepine on the Pharmacokinetics of Paliperidone Extended Release (ER) in Patients With Schizophrenia or Bipolar I Disorder
Lead Sponsor:
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Conditions:
Schizophrenia
Bipolar Disorder
Eligibility:
All Genders
18-55 years
Phase:
PHASE1
Brief Summary
The purposes of this study are to evaluate the effects of a potent metabolic enzyme inducer, carbamazepine, on the steady-state pharmacokinetics of orally administered paliperidone ER and to evaluate ...
Detailed Description
The current study is designed as an open-label, multiple-center, multiple-dose, 2 treatment, 2 period sequential drug interaction study. It consists of 3 phases: a screening phase beginning within 21 ...
Eligibility Criteria
Inclusion
- Diagnosis of schizophrenia of any subtype (295.10
- 20
- 30
- 60
- 90) or bipolar I disorder (296.0x, 296.4x, 296.5x, 296.6x or 296.7), according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)
- Clinically stable with no psychiatric hospitalization or change in existing mood stabilizers, antipsychotic, or anti-manic drugs for 3 months before screening. A reduction in the dose of existing medication is acceptable if the subject remained clinically stable throughout the 3 month period. In addition, an increase or decrease in the dose of a mood stabilizer on the basis of therapeutic drug monitoring or the substitution of a specific mood stabilizer, antipsychotic, or anti-manic drug for another because of poor tolerability will be allowed within 3 months before screening
- Have a CGI-S score of 3 or less at baseline and at screening
- Body mass index (BMI, weight \[kg\]/height \[m2\]) of 18 to 35 kg/m2, inclusive
- Have a supine (after 5 minutes rest) blood pressure between 100 and 140 mmHg systolic, inclusive, and 50 and 90 mmHg diastolic, inclusive
- Apart from the above-mentioned diagnosis, otherwise healthy on the basis of a prestudy physical examination, medical history, 12-lead ECG, and the laboratory results of serum chemistry, hematology, and urinalysis performed within 21 days before the first dose. For renal function tests, the values must be within the normal laboratory reference ranges
- Women must be postmenopausal for at least 2 years, surgically sterile, abstinent, or practicing or agree to practice an effective method of birth control if they are sexually active before entry and throughout the study (effective methods of birth control include intrauterine devices, double-barrier method, and male partner sterilization). Prescription hormonal contraceptives must be used in combination with another method of birth control (e.g., double-barrier method) throughout the study. Women of childbearing potential must have a negative serum pregnancy test result at screening, and a negative urine test at baseline (Day 1).
Exclusion
- Diagnosis of schizoaffective disorder (295.70) according to the DSM-IV
- Meet DSM-IV criteria for rapid cycling
- DSM-IV diagnosis of alcohol or substance dependence, with the exception of nicotine or caffeine dependence, within 12 months before screening. Intermittent substance abuse in the months before screening will not be exclusionary, depending upon the clinical judgment of the investigator, with the exception of barbiturates
- Acute substance abuse, as evidenced by a positive urine drug screen at screening or baseline (Day 1)
- Positive alcohol test at screening or baseline (Day 1)
- Current suicidal ideation or violent tendencies at the time of screening
- Involuntarily-hospitalized subjects
- Moderate or severe tardive dyskinesia at the time of screening
- History of neuroleptic malignant syndrome
- History of bone marrow depression or acute intermittent porphyria
- History of or a positive result at screening for any of the serology tests (hepatitis B, C, and human immunodeficiency virus \[HIV\])
- History or presence of any relevant cardiovascular (including myocardial infarct or cardiac arrhythmia), respiratory, neurologic (including seizures), renal, hepatic, gastrointestinal (including surgeries, severe gastrointestinal narrowing, and malabsorption problems), endocrine, hematologic, or immunologic disease
Key Trial Info
Start Date :
September 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2007
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT00892125
Start Date
September 1 2006
End Date
March 1 2007
Last Update
May 18 2011
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